Wednesday, January 31, 2018

College Experiences for Students with Autism Spectrum Disorder

College Experiences for Students with Autism Spectrum Disorder


Thirty years ago it was rare for a student with autism spectrum disorder (ASD) to enter college. However, over the past decades with the increased awareness and detection of ASD in children with average or above average intellectual abilities (Christensen et al. 2016) and with the improved provisions of effective, evidence-based treatments (Reichow and Volkmar 2011) many students with ASD are now seeking enrollment in college (Volkmar et al. 2017). In the USA alone there are roughly 550,000 children with ASD who will be transitioning into adulthood over the next decade (Buescher et al. 2014), and it is expected that approximately 45% of these emerging adults will enroll in a university,
college, or technical/vocational school in the coming years (Newman et al.
2011). This is a promising trend, as completion of a post-secondary degree is a significant predictor of positive adult outcomes in ASD populations, impacting the likelihood that an individual will be able to find employment, obtain financial independence, and live independently. However, students with ASD have a lower likelihood of completing their degree (38.8%) compared to students from the general population (52.4%) and those with disabilities in general (40.7%; Newman et al. 2011).

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Thursday, January 25, 2018

Maternal multivitamin intake, plasma folate and vitamin B12 levels and Autism Spectrum Disorder risk in offspring

Maternal multivitamin intake, plasma folate and vitamin B12levels and Autism Spectrum Disorder risk in  offspring

Abstract
Background—To examine the prospective association between multivitamin supplementation
during pregnancy and biomarker measures of maternal plasma folate and vitamin B
12 levels at
birth and child's Autism Spectrum Disorder (ASD) risk.


Methods—This report included 1257 mother-child pairs, who were recruited at birth and
prospectively followed through childhood at the Boston Medical Center. ASD was defined from
diagnostic codes in electronic medical records. Maternal multivitamin supplementation was
assessed via questionnaire interview; maternal plasma folate and B
12 were measured from samples
taken 2-3 days after birth.


Results—Moderate (3-5 times/week) self-reported supplementation during pregnancy was
associated with decreased risk of ASD, consistent with previous findings. Using this as the
 reference group, low (≤2 times/week) and high (>5 times/week) supplementation was associatedwith increased risk of ASD. Very high levels of maternal plasma folate at birth (≥60.3 nmol/L) had2.5 times increased risk of ASD (95% confidence interval [CI] 1.3, 4.6) compared to folate levelsin the middle 80th percentile, after adjusting for covariates including MTHFR genotype. Similarly,very high B12 (≥536.8 pmol/L) showed 2.5 times increased risk (95% CI 1.4, 4.5).

Conclusion—There was a “U” shaped relationship between maternal multivitamin
supplementation frequency and ASD risk. Extremely high maternal plasma folate and B12 levels at
birth were associated with ASD risk. This hypothesis-generating study does not question the
importance of consuming adequate folic acid and vitamin B12 during pregnancy; rather, raises new
questions about the impact of extremely elevated levels of plasma folate and B12 exposure in-utero
on early brain development.

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